期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 28
卷 28, 期 -, 页码 555-573出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-101011-155822
关键词
long interspersed element-1 (L1); mobile element; DNA transposon; neurogenesis; neural development; brain evolution
资金
- NIH HHS [1-DP2-OD006495-01] Funding Source: Medline
- NIMH NIH HHS [R01 MH094753-01] Funding Source: Medline
- NINDS NIH HHS [1F31NS076198-01A1] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH094753] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [F31NS076198] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD006495] Funding Source: NIH RePORTER
Long interspersed element-1 (LINE-1 or L1) is a repetitive DNA retrotransposon capable of duplication by a copy-and-paste genetic mechanism. Scattered throughout mammalian genomes, L1 is typically quiescent in most somatic cell types. In developing neurons, however, L1 can express and retrotranspose at high frequency. The L1 element can insert into various genomic locations including intragenic regions. These insertions can alter the dynamic of the neuronal transcriptome by changing the expression pattern of several nearby genes. The consequences of L1 genomic alterations in somatic cells are still under investigation, but the high level of mutagenesis within neurons suggests that each neuron is genetically unique. Furthermore, some neurological diseases, such as Rett syndrome and ataxia telangiectasia, misregulate L1 retrotransposition, which could contribute to some pathological aspects. In this review, we survey the literature related to neurodevelopmental retrotransposition and discuss possible relevance to neuronal function, evolution, and neurological disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据