期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27
卷 27, 期 -, 页码 265-290出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-092910-154013
关键词
triple helix; cell-collagen interaction; integrin; receptor tyrosine kinase; cell adhesion; hemostasis
资金
- Medical Research Council [G0701121] Funding Source: Medline
- MRC [G0701121] Funding Source: UKRI
Collagen, the most abundant protein in animals, is a key component of extracellular matrices. Not only do collagens provide essential structural support for connective tissues, but they are also intimately involved in controlling a spectrum of cellular functions such as growth, differentiation, and morphogenesis. All collagens possess triple-helical regions through which they interact with a host of other proteins including cell surface receptors. A structurally diverse group of transmembrane receptors mediates the recognition of the collagen triple helix: integrins, discoidin domain receptors, glycoprotein VI, and leukocyte-associated immunoglobulin-like receptor-1. These collagen receptors regulate a wide range of behaviors including cell adhesion and migration, hemostasis, and immune function. Here these collagen receptors are discussed in terms of their molecular basis of collagen recognition, their signaling and developmental functions, and their roles in disease.
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