期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 20, 期 12, 页码 2245-2253出版社
WILEY
DOI: 10.1359/JBMR.050816
关键词
osteoclast; apoptosis; Rac1; Akt; macrophage colony-stimulating factor
The role of Rac1 in osteoclast survival and bone-resorbing activity was examined using adenovirus vector expression systems. Rac1 is critically involved in M-CSF receptor signaling and mediates survival signaling primarily through PI3K/Akt pathways. Rac1 also plays a significant role in bone resorptive activity, probably by regulating the motility of osteoclasts.
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