期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 26
卷 26, 期 -, 页码 689-719出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100109-104113
关键词
bet-hedging; color vision; olfaction; spinal cord; lateral inhibition
资金
- NEI NIH HHS [R01 EY013010-13, R01 EY013010] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY013010] Funding Source: NIH RePORTER
Although cell fate specification is tightly controlled to yield highly reproducible results and avoid extreme variation, developmental programs often incorporate stochastic mechanisms to diversify cell types. Stochastic specification phenomena are observed in a wide range of species and an assorted set of developmental contexts. In bacteria, stochastic mechanisms are utilized to generate transient subpopulations capable of surviving adverse environmental conditions. In vertebrate, insect, and worm nervous systems, stochastic fate choices are used to increase the repertoire of sensory and motor neuron subtypes. Random fate choices are also integrated into developmental programs controlling organogenesis. Although stochastic decisions can be maintained to produce a mosaic of fates within a population of cells, they can also be compensated for or directed to yield robust and reproducible outcomes.
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