期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
卷 25, 期 -, 页码 253-275出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.cellbio.042308.113256
关键词
neural stem cells (NSCs); hippocampus; olfactory bulb; niche; plasticity
资金
- KIBM Innovative Research Award
- James S. McDonnell Foundation
- U.S. National Institutes of Health [NS-050217]
- Mathers Foundation
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS050217] Funding Source: NIH RePORTER
The identification of neural stem cells (NSCs) and their contribution to continuous neurogenesis has shown that the hippocampus and olfactory bulb are plastic. Brain plasticity, achieved at the level of cell genesis, has an essential role in the maintenance of brain homeostasis. Via combinatorial functions of extrinsic signals and intrinsic programs, adult neurogenesis is tightly regulated in a specialized microenvironment, a niche. Misregulated neurogenesis is detrimental to normal brain functions and, in extreme cases, pathogenic. Hence, understanding signaling in adult neurogenesis is not only important to understand the physiological roles of neurogenesis, but also to provide knowledge that is essential for developing therapeutic applications using NSCs to intervene in the progression of brain diseases.
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