期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
卷 25, 期 -, 页码 45-69出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.cellbio.042308.113259
关键词
lineage; stem cell; neuron; Muller glia; ciliary margin
资金
- Gonville and Caius College, Cambridge
- Wellcome Trust
Multipotent retinal progenitors undergo a varied number of divisions to produce clones of heterogeneous sizes and cell types. We describe the transition from a proliferating progenitor to a differentiated post-mitotic cell and discuss how controls of proliferation operate within individual cells as well as in the whole tissue. We discuss how extracellular and intracellular signaling, transcriptional regulation, cell cycle kinetics, interkinetic nuclear migration, orientation of cell division, and epigenetic modifications all interact to regulate a progenitor's transition from division to differentiation. We also propose some directions for future research.
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