期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
卷 25, 期 -, 页码 197-220出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.cellbio.24.110707.175242
关键词
organ and tissue size; imaginal disc; cell competition; pattern regulation; cell-cell interactions
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD042770] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM078464] Funding Source: NIH RePORTER
- NICHD NIH HHS [R01 HD042770-04, R01 HD042770-05, R01 HD042770, R01 HD042770-03, R01 HD042770-02] Funding Source: Medline
- NIGMS NIH HHS [R01 GM078464-02, R01 GM078464-03, R01 GM078464-01, R01 GM078464] Funding Source: Medline
Animal shape and size is controlled with amazing precision during development. External factors such as nutrient availability and crowding can alter overall animal size, but individual body parts scale reproducibly to match the body even with challenges from a changing environment. How is such precision achieved? Here, we review selected research from the last few years in Drosophila-arguably the premier genetic model for the study of animal growth-that sheds light on how body and tissue size are regulated by forces intrinsic to individual organs. We focus on two topics currently under intense study: the influence of pattern regulators on organ and tissue growth and the role of local competitive interactions between cells in tissue homeostasis and final size.
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