期刊
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
卷 24, 期 -, 页码 397-424出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.cellbio.23.090506.123245
关键词
meiosis; homologous chromosomes; pairing; synapsis; recombination; meiotic bouquet
资金
- NIH [K99RR0241110, R01 GM065591]
- NATIONAL CENTER FOR RESEARCH RESOURCES [K99RR024110] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007790, R01GM065591] Funding Source: NIH RePORTER
Accurate segregation of chromosomes during meiosis requires physical links between homologs. These links are usually established through chromosome pairing, synapsis, and recombination, which occur during meiotic prophase. How chromosomes pair with their homologous partners is one of the outstanding mysteries of meiosis. Surprisingly experimental evidence indicates that different organisms have found more than one way, to accomplish this fear. Whereas some species depend on recombination machinery to achieve homologous pairing, others are able to pair and synapse their homologs in the absence of recombination. To ensure specific pairing between homologous chromosomes, both recombination-dependent and recombination independent mechanisms must strike the proper balance between forces that promote chromosome interactions and activities that temper the promiscuity of those interactions. The initiation of synapsis is likely to be a tightly regulated step in a process that must be mechanically coupled to homolog pairing.
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