期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 43
卷 43, 期 -, 页码 331-355出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-051013-022826
关键词
itch; pruritus; neurons; neural circuits; sensitization; pain
类别
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIDCR NIH HHS [R01 DE022750, DE022750] Funding Source: Medline
- NIGMS NIH HHS [GM087369, R01 GM087369] Funding Source: Medline
- NINDS NIH HHS [K99 NS087088, NS054791, R01 NS054791] Funding Source: Medline
The itch-scratch reflex serves as a protective mechanism in everyday life. However, chronic persistent itching can be devastating. Despite the clinical importance of the itch sensation, its mechanism remains elusive. In the past decade, substantial progress has been made to uncover the mystery of itching. Here, we review the molecules, cells, and circuits known to mediate the itch sensation, which, coupled with advances in understanding the pathophysiology of chronic itching conditions, will hopefully contribute to the development of new anti-itch therapies.
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