期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 42
卷 42, 期 -, 页码 191-215出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-083012-130422
关键词
antibody; T cell receptor; variable lymphocyte receptor; jawless vertebrate; immunoglobulin fold; leucine-rich repeat
类别
资金
- NIAID NIH HHS [AI036900, R01 AI036900, AI073654] Funding Source: Medline
The adaptive immune system, which is based on highly diverse antigen receptors that are generated by somatic recombination, arose approximately 500 Mya at the dawn of vertebrate evolution. In jawed vertebrates, adaptive immunity is mediated by antibodies and T cell receptors (TCRs), which are composed of immunoglobulin (Ig) domains containing hypervariable loops that bind antigen. In striking contrast, the adaptive immune receptors of jawless vertebrates, termed variable lymphocyte receptors (VLRs), are constructed from leucine-rich repeat (LRR) modules. Structural studies of VLRs have shown that these LRR-based receptors bind antigens though their concave surface, in addition to a unique hypervariable loop in the C-terminal LRR capping module. These studies have revealed a remarkable example of convergent evolution in which jawless vertebrates adopted the LRR scaffold to recognize as broad a spectrum of antigens as the Ig-based antibodies and TCRs of jawed vertebrates, with altogether comparable affinity and specificity.
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