期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 41
卷 41, 期 -, 页码 227-246出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-050511-102252
关键词
actin-binding protein; mechanosensor; mechanotransduction; extracellular matrix; cytoskeleton
类别
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM068600] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM-068600, R01 GM068600] Funding Source: Medline
Filamins are essential, evolutionarily conserved, modular, multidomain, actin-binding proteins that organize the actin cytoskeleton and maintain extracellular matrix connections by anchoring actin filaments to transmembrane receptors. By cross-linking and anchoring actin filaments, filamins stabilize the plasma membrane, provide cellular cortical rigidity, and contribute to the mechanical stability of the plasma membrane and the cell cortex. In addition to binding actin, filamins interact with more than 90 other binding partners including intracellular signaling molecules, receptors, ion channels, transcription factors, and cytoskeletal and adhesion proteins. Thus, filamins scaffold a wide range of signaling pathways and are implicated in the regulation of a diverse array of cellular functions including motility, maintenance of cell shape, and differentiation. Here, we review emerging structural and functional evidence that filamins are mechanosensors and/or mechanotransducers playing essential roles in helping cells detect and respond to physical forces in their local environment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据