期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 41
卷 41, 期 -, 页码 543-556出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-042910-155238
关键词
cytoskeleton; signal transduction; spatial mutation
类别
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [U54 CA143836] Funding Source: Medline
- NEI NIH HHS [PN2EY016586, PN2 EY016586] Funding Source: Medline
- NIAID NIH HHS [R37AI43542, R37 AI043542] Funding Source: Medline
Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction systems. Molecular level clustering, spatial exclusion, and long-range directed transport are all emerging as key regulatory mechanisms. The study of these processes is drawing researchers from physical sciences to join the effort and represents a rapidly growing branch of biophysical chemistry. Recent advances in physical and quantitative analyses of signaling within the immune synapses are reviewed here.
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