期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 41
卷 41, 期 -, 页码 557-584出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-050511-102328
关键词
assembly; cryo-electron tomography; gene regulation; nucleocytoplasmic transport; nucleoporin; structure
类别
The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous translocation channels that allow the free diffusion of small molecules and ions, as well as receptor-mediated transport of large macromolecules. The NPC regulates nucleocytoplasmic transport of macromolecules, utilizing soluble receptors that identify and present cargo to the NPC, in a highly selective manner to maintain cellular functions. The NPC is composed of multiple copies of approximately 30 different proteins, termed nucleoporins, which assemble to form one of the largest multiprotein assemblies in the cell. In this review, we address structural and functional aspects of this fundamental cellular machinery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据