期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 40
卷 40, 期 -, 页码 267-288出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-042910-155310
关键词
microtubule; molecular motor; intracellular transport; autoinhibition; bidirectional transport; posttranslational modifications
类别
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM070862] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM070862] Funding Source: Medline
Long-distance transport in eukaryotic cells is driven by molecular motors that move along microtubule tracks. Molecular motors of the kinesin superfamily contain a kinesin motor domain attached to family-specific sequences for cargo binding, regulation, and oligomerization. The biochemical and biophysical properties of the kinesin motor domain have been widely studied, yet little is known about how kinesin motors work in the complex cellular environment. We discuss recent studies on the three major families involved in intracellular transport (kinesin-1, kinesin-2, and kinesin-3) that have begun to bridge the gap in knowledge between the in vitro and in vivo behaviors of kinesin motors. These studies have increased our understanding of how kinesin subunits assemble to produce a functional motor, how kinesin motors are affected by biochemical cues and obstacles present on cellular microtubules, and how multiple motors on a cargo surface can work collectively for increased force production and travel distance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据