期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 39
卷 39, 期 -, 页码 207-226出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.biophys.093008.131238
关键词
membrane rafts; lipid nanodomains; line tension; continuum theory; Monte Carlo simulation; nanoscopic detection
类别
资金
- NHLBI NIH HHS [K25 HL079165-04, K25 HL079165, HL079165] Funding Source: Medline
- NIGMS NIH HHS [R01 GM084200, GM084200, R01 GM084200-02] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K25HL079165] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM084200] Funding Source: NIH RePORTER
- Directorate For Engineering [0825839, 0826518] Funding Source: National Science Foundation
Lipid bilayer model membranes that contain a single lipid species can undergo transitions between ordered and disordered phases, and membranes that contain a mixture of lipid species can undergo phase separations. Studies of these transformations are of interest for what they can tell us about the interaction energies of lipid molecules of different species and conformations. Nanoscopic phases (<200 nm) can provide a model for membrane rafts, specialized membrane domains enriched in cholesterol and sphingomyelin, which are believed to have essential biological functions in cell membranes. Crucial questions are whether lipid nanodomains can exist in stable equilibrium in membranes and what is the distribution of their sizes and lifetimes in membranes of different composition. Theoretical methods have supplied much information on these questions, but better experimental methods are needed to detect and characterize nanodomains under normal membrane conditions. This review summarizes linkages between theoretical and experimental studies of phase separation in lipid bilayer model membranes.
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