期刊
ANNUAL REVIEW OF BIOPHYSICS, VOL 39
卷 39, 期 -, 页码 559-578出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.biophys.093008.131357
关键词
sphingolipids; microdomains; Golgi; secretion; endocytosis partitioning; modeling
类别
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [ZIAHD001609] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM079305] Funding Source: NIH RePORTER
- Intramural NIH HHS [ZIA HD001609-17] Funding Source: Medline
- NIGMS NIH HHS [R01 GM079305-04, R01 GM079305] Funding Source: Medline
The endomembrane system of eukaryotic cells uses membrane-enclosed carriers to move diverse macromolecules among different membrane-bound compartments, a requirement for cells to secrete and take up molecules from their environment. Two recycling pathways-biosynthetic and endocytic, each with specific lipid components make up this system, with the Golgi apparatus mediating transport between the two. Here, we integrate lipid-based mechanisms into the description of this system. A partitioning model of the Golgi apparatus is discussed as a working hypothesis to explain how membrane lipids and proteins that are segregated based on lateral lipid partitioning support the unique composition of the biosynthetic and endocytic recycling pathways in the face of constant trafficking of molecular constituents. We further discuss how computational modeling can allow for interpretation of experimental findings and provide mechanistic insight into these important cellular pathways.
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