期刊
ANNUAL REVIEW OF BIOPHYSICS
卷 37, 期 -, 页码 135-151出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.biophys.36.040306.132812
关键词
free energy; enthalpy; entropy; binding; rational drug design
类别
资金
- NCI NIH HHS [CA35635] Funding Source: Medline
- NIGMS NIH HHS [GM077422] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA035635] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM077422] Funding Source: NIH RePORTER
Modern instrumentation for calorimetry permits direct determination of enthalpy values for binding reactions and conformational transitions in biomolecules. Complete thermodynamic profiles consisting of free energy, enthalpy, and entropy may be obtained for reactions of interest in a relatively straightforward manner. Such profiles are of enormous value in drug design because they provide information about the balance of driving forces that cannot be obtained from structural or computational methods alone. This perspective shows several examples of the insight provided by thermodynamic data in drug design.
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