期刊
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 16
卷 16, 期 -, 页码 103-129出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-071813-104733
关键词
optogenetics; neurophysiology; imaging; channelrhodopsin; halorhodopsin; GCaMP
资金
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1247950] Funding Source: National Science Foundation
- Howard Hughes Medical Institute Funding Source: Medline
- NEI NIH HHS [R01 EY022951] Funding Source: Medline
- NIDA NIH HHS [R37 DA035377] Funding Source: Medline
- NIMH NIH HHS [R01 MH099647] Funding Source: Medline
Genetically encoded optical actuators and indicators have changed the landscape of neuroscience, enabling targetable control and readout of specific components of intact neural circuits in behaving animals. Here, we review the development of optical neural interfaces, focusing on hardware designed for optical control of neural activity, integrated optical control and electrical readout, and optical readout of population and single-cell neural activity in freely moving mammals.
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