期刊
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 16
卷 16, 期 -, 页码 371-396出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-121813-120704
关键词
high throughput; particle separation; label-free cell separation; biofluid processing; hydrodynamic lift; applied physics
资金
- NIBIB NIH HHS [P41 EB002503, U01 EB012493] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [U01EB012493, P41EB002503] Funding Source: NIH RePORTER
When Segre and Silberberg in 1961 witnessed particles in a laminar pipe flow congregating at an annulus in the pipe, scientists were perplexed and spent decades learning why such behavior occurred, finally understanding that it was caused by previously unknown forces on particles in an inertial flow. The advent of microfluidics opened a new realm of possibilities for inertial focusing in the processing of biological fluids and cellular suspensions and created a field that is now rapidly expanding. Over the past five years, inertial focusing has enabled high-throughput, simple, and precise manipulation of bodily fluids for a myriad of applications in point-of-care and clinical diagnostics. This review describes the theoretical developments that have made the field of inertial focusing what it is today and presents the key applications that will make inertial focusing a mainstream technology in the future.
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