期刊
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 14
卷 14, 期 -, 页码 205-230出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-071811-150052
关键词
vascular models; microcirculation; tissue engineering; chemical gradients; tumor angiogenesis; microfluidic hydrogels
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R21HL092335] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB005792] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL092335] Funding Source: Medline
- NIBIB NIH HHS [EB005792] Funding Source: Medline
In vitro studies of vascular physiology have traditionally relied on cultures of endothelial cells, smooth muscle cells, and pericytes grown on centimeter-scale plates, filters, and flow chambers. The introduction of microfluidic tools has revolutionized the study of vascular physiology by allowing researchers to create physiologically relevant culture models, at the same time greatly reducing the consumption of expensive reagents. By taking advantage of the small dimensions and laminar flow inherent in microfluidic systems, recent studies have created in vitro models that reproduce many features of the in vivo vascular microenvironment with fine spatial and temporal resolution. In this review, we highlight the advantages of microfluidics in four areas: the investigation of hemodynamics on a capillary length scale, the modulation of fluid streams over vascular cells, angiogenesis induced by the exposure of vascular cells to well-defined gradients in growth factors or pressure, and the growth of microvascular networks in biomaterials. Such unique capabilities at the microscale are rapidly advancing the understanding of microcirculatory dynamics, shear responses, and angiogenesis in health and disease as well as the ability to create in vivo-like blood vessels in vitro.
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