期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83
卷 83, 期 -, 页码 129-157出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-060713-035314
关键词
heparin-binding protein; glycosaminoglycan; proteoglycan; glycan-protein interaction; heparan sulfate-binding domain; oligomerization
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL107150] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM093131] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL107150, P01 HL107150] Funding Source: Medline
- NIGMS NIH HHS [GM093131, R01 GM093131] Funding Source: Medline
Numerous proteins, including cytokines and chemokines, enzymes and enzyme inhibitors, extracellular matrix proteins, and membrane receptors, bind heparin. Although they are traditionally classified as heparin-binding proteins, under normal physiological conditions these proteins actually interact with the heparan sulfate chains of one or more membrane or extracellular proteoglycans. Thus, they are more appropriately classified as heparan sulfate-binding proteins (HSBPs). This review provides an overview of the various modes of interaction between heparan sulfate and HSBPs, emphasizing biochemical and structural insights that improve our understanding of the many biological functions of heparan sulfate.
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