期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83
卷 83, 期 -, 页码 671-696出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-051810-093157
关键词
epigenetics; histone; nucleosome; SWI/SNF; ISWI; CHD; ATRX; INO80; SWR1; cancer; differentiation; transcription
资金
- NIGMS NIH HHS [R01 GM048413] Funding Source: Medline
Alarge family of chromatin remodelers that noncovalently modify chromatin is crucial in cell development and differentiation. They are often the targets of cancer, neurological disorders, and other human diseases. These complexes alter nucleosome positioning, higher-order chromatin structure, and nuclear organization. They also assemble chromatin, exchange out histone variants, and disassemble chromatin at defined locations. We review aspects of the structural organization of these complexes, the functional properties of their protein domains, and variation between complexes. We also address the mechanistic details of these complexes in mobilizing nucleosomes and altering chromatin structure. A better understanding of these issues will be vital for further analyses of subunits of these chromatin remodelers, which are being identified as targets in human diseases by NGS (next-generation sequencing).
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