期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 82
卷 82, 期 -, 页码 387-414出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-060410-105307
关键词
APC/C; cell cycle checkpoint; cyclin-dependent kinase; mitosis; SCF; ubiquitylation
资金
- NIH [CA074224, CA078343]
- Pew Latin American Fellows Program in the Biomedical Sciences
- NATIONAL CANCER INSTITUTE [R56CA078343, R01CA078343, R01CA074224] Funding Source: NIH RePORTER
The ubiquitin-proteasome system plays a pivotal role in the sequence of events leading to cell division known as the cell cycle. Not only does ubiquitin-mediated proteolysis constitute a critical component of the core oscillator that drives the cell cycle in all eukaryotes, it is also central to the mechanisms that ensure that the integrity of the genome is maintained. These functions are primarily carried out by two families of E3 ubiquitin ligases, the Skp/cullin/F-box-containing and anaphase-promoting complex/cyclosome complexes. However, beyond those functions associated with regulation of central cell cycle events, many peripheral cell cycle-related processes rely on ubiquitylation for signaling, homeostasis, and dynamicity, involving additional types of ubiquitin ligases and regulators. We are only beginning to understand the diversity and complexity of this regulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据