期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 82
卷 82, 期 -, 页码 663-+出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-072909-101058
关键词
multivesicular bodies; membrane protein degradation; exosomes; shedding microvesicles; virus budding; cytokinesis; abscission
资金
- National Institutes of Health [AI051174, GM082545]
- American Cancer Society [PF-11-279-01-CCG]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI051174] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM082545] Funding Source: NIH RePORTER
The endosomal sorting complexes required for transport (ESCRT) pathway was initially defined in yeast genetic screens that identified the factors necessary to sort membrane proteins into intraluminal endosomal vesicles. Subsequent studies have revealed that the mammalian ESCRT pathway also functions in a series of other key cellular processes, including formation of extracellular microvesicles, enveloped virus budding, and the abscission stage of cytokinesis. The core ESCRT machinery comprises Bro1 family proteins and ESCRT-I, ESCRT-II, ESCRT-III, and VPS4 complexes. Site-specific adaptors recruit these soluble factors to assemble on different cellular membranes, where they carry out membrane fission reactions. ESCRT-III proteins form filaments that draw membranes together from the cytoplasmic face, and mechanistic models have been advanced to explain how ESCRT-III filaments and the VPS4 ATPase can work together to catalyze membrane fission.
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