期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81
卷 81, 期 -, 页码 145-166出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-051410-092902
关键词
functional genomics; chromatin; histone modifications; epigenetics
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [R01-CA118750, R01 CA118750] Funding Source: Medline
- NHGRI NIH HHS [R01-HG004361, R01 HG004361] Funding Source: Medline
- NIGMS NIH HHS [1P01GM099117-01, P01 GM099117] Funding Source: Medline
- NIH HHS [1DP2OD00667-01] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA118750] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG004361] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM099117] Funding Source: NIH RePORTER
The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which in turn serve as the template for protein synthesis. The discovery of extensive transcription of large RNA transcripts that do not code for proteins, termed long noncoding RNAs (lncRNAs), provides an important new perspective on the centrality of RNA in gene regulation. Here, we discuss genome-scale strategies to discover and characterize lncRNAs. An emerging theme from multiple model systems is that lncRNAs form extensive networks of ribonucleoprotein (RNP) complexes with numerous chromatin regulators and then target these enzymatic activities to appropriate locations in the genome. Consistent with this notion, lncRNAs can function as modular scaffolds to specify higher-order organization in RNP complexes and in chromatin states. The importance of these modes of regulation is underscored by the newly recognized roles of long RNAs for proper gene control across all kingdoms of life.
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