期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80
卷 80, 期 -, 页码 797-823出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-061809-152236
关键词
carbohydrate; glycan-binding protein; glycomics; lectin
资金
- NCI NIH HHS [R01 CA138891] Funding Source: Medline
- NIAID NIH HHS [P01 AI058113, P01 AI058113-07, P01 AI058113-01, AI058113, T32 AI007606, AI 007606] Funding Source: Medline
- NIGMS NIH HHS [U54 GM062116, GM60938, U54 GM062116-10, R01 GM060938-10, GM62116, R01 GM060938-10S1, R01 GM060938, U54 GM062116-09] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA138891] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI058113, T32AI007606] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM060938, U54GM062116] Funding Source: NIH RePORTER
In the last decade, glycan microarrays have revolutionized the analysis of the specificity of glycan-binding proteins (GBPs), providing information that simultaneously illuminates the biology mediated by them and decodes the informational content of the glycome. Numerous methods have emerged for arraying glycans in a chip format, and glycan libraries have been assembled that address the diversity of the human glycome. Such arrays have been successfully used for analysis of GBPs, which mediate mammalian biology, host-pathogen interactions, and immune recognition of glycans relevant to vaccine production and cancer antigens. This review covers the development of glycan microarrays and applications that have provided insights into the roles of mammalian and microbial GBPs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据