期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80
卷 80, 期 -, 页码 375-+出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-060409-093259
关键词
signal transduction; imaging; biosensor; FRET; spatiotemporal dynamics
资金
- NIDDK NIH HHS [P30 DK079637, R01DK073368, R01 DK073368] Funding Source: Medline
- NIH HHS [DP1OD006419, DP1 OD006419] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK073368, P30DK079637] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD006419] Funding Source: NIH RePORTER
Real-time visualization of a wide range of biochemical processes in living systems is being made possible through the development and application of genetically encoded fluorescent reporters. These versatile biosensors have proven themselves tailor-made to the study of signal transduction, and in this review, we discuss some of the unique insights that they continue to provide regarding the spatial organization and dynamic regulation of intracellular signaling networks. In addition, we explore the more recent push to expand the scope of biological phenomena that can be monitored using these reporters, while also considering the potential to integrate this highly adaptable technology with a number of emerging techniques that may significantly broaden our view of how networks of biochemical processes shape larger biological phenomena.
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