期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80
卷 80, 期 -, 页码 333-355出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-061009-091643
关键词
cell imaging; fluorescent probes
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [K99GM092970, R01GM065519] Funding Source: NIH RePORTER
- NIGMS NIH HHS [K99 GM092970, K99 GM092970-01, K99GM092970, R01 GM065519-10, R01 GM065519, GM065519, R01 GM065519-01] Funding Source: Medline
Biological mobile zinc and nitric oxide (NO) are two prominent examples of inorganic compounds involved in numerous signaling pathways in living systems. In the past decade, a synergy of regulation, signaling, and translocation of these two species has emerged in several areas of human physiology, providing additional incentive for developing adequate detection systems for Zn(II) ions and NO in biological specimens. Fluorescent probes for both of these bioinorganic analytes provide excellent tools for their detection, with high spatial and temporal resolution. We review the most widely used fluorescent sensors for biological zinc and nitric oxide, together with promising new developments and unmet needs of contemporary Zn(II) and NO biological imaging. The interplay between zinc and nitric oxide in the nervous, cardiovascular, and immune systems is highlighted to illustrate the contributions of selective fluorescent probes to the study of these two important bioinorganic analytes.
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