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MOLECULAR CELL (2008)
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Ubiquitin-dependent proteolytic control of SUMO conjugates
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation
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Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway
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A proteomic screen reveals sCFGrr1 targets that regulate the glycolytic-gluconeogenic switch
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NATURE CELL BIOLOGY (2007)
Targeted inactivation of mdm2 RING finger e3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
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CANCER CELL (2007)
E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
SUMO-targeted ubiquitin ligases in genome stability
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EMBO JOURNAL (2007)
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EMBO JOURNAL (2007)
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Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression
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BIOCHEMICAL JOURNAL (2007)
Sequential E2s drive polyubiquitin chain assembly on APC targets
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CELL (2007)
Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin
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JOURNAL OF MOLECULAR BIOLOGY (2007)
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase
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MOLECULAR CELL (2007)
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination
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CELL (2007)
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages
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Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structure of a Fbw7-Skp1-cyclin E complex: Multisite-phosphorylated substrate recognition by SCF ubiquitin ligases
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MOLECULAR CELL (2007)
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Mad3 KEN Boxes Mediate both Cdc20 and Mad3 Turnover, and Are Critical for the Spindle Checkpoint
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A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate
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Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of IκB kinase activation
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Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity
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Fbw7/hCDC4 dimerization regulates its substrate interactions
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CELL DIVISION (2007)
The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity
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Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complex
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A ubiquitin ligase complex assembles linear polyubiquitin chains
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EMBO JOURNAL (2006)
Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation
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Control of methionine biosynthesis genes by protein kinase CK2-mediated phosphorylation of Cdc34
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Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
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SCFβTrCP-mediated degradation of claspin regulates recovery from the DNA replication checkpoint response
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MOLECULAR CELL (2006)
Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate
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Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology
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NATURE CELL BIOLOGY (2006)
A ubiquitin-interacting motif protects polyubiquitinated Met4 from degradation by the 26S proteasome
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NATURE CELL BIOLOGY (2006)
A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination
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MOLECULAR CELL (2006)
Lingering mysteries of ubiquitin-chain assembly
M Hochstrasser
CELL (2006)
A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase
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The processivity of multiubiquitination by the APC determines the order of substrate degradation
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The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain,, RING finger, and an E2-binding site
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases
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Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases
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Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis
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MOLECULAR CELL (2005)
E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer
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Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
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A dynamic role of HAUSP in the p53-Mdm2 pathway
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Y Li et al.
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XJ Wang et al.
FEBS LETTERS (2004)
An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair
GS Winkler et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase
T Bashir et al.
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Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
W Wei et al.
NATURE (2004)
Mass spectrometric and mutational analyses reveal lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase
H Nishikawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
SJ Goldenberg et al.
CELL (2004)
Role of histone H2A ubiquitination in polycomb silencing
HB Wang et al.
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Autoubiquitylation of the V(D)J recombinase protein RAG1
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
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A conserved catalytic residue in the ubiquitin-conjugating enzyme family
PY Wu et al.
EMBO JOURNAL (2003)
Mathematical modeling suggests cooperative interactions between a disordered polyvalent ligand and a single receptor site
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COP9 signalosome: A multifunctional regulator of SCF and other cullin-based ubiquitin Ligases
GA Cope et al.
CELL (2003)
The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin
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Release of ubiquitin-charged Cdc34-S∼Ub from the RING domain is essential for ubiquitination of the SCFCdc4-bound substrate Sic1
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Context of multiubiquitin chain attachment influences the rate of Sic1 degradation
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Binding and recognition in the assembly of an active BRCA1 /BARD1 ubiquitin-ligase complex
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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
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NATURE CELL BIOLOGY (2003)
The RAG1 N-terminal domain is an E3 ubiquitin ligase
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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase
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CELL (2003)
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A conserved RING finger protein required for histone H2B monoubiquitination and cell size control
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Scores of RINGs but No PHDs in Ubiquitin Signaling
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Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains
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EMBO JOURNAL (2002)
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
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NEDD8 modification of CUL1 short article dissociates p120CAND1, an inhibitor of CULl-SKP1 binding and SCIF ligases
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Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors
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CW Carroll et al.
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JW Harper et al.
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NATURE (2002)
CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with β-TrCP and enhances β-catenin degradation
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NATURE CELL BIOLOGY (2002)
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
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NATURE CELL BIOLOGY (2002)
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Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation
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EMBO JOURNAL (2002)
Pseudosubstrate regulation of the SCFβ-TrCP ubiquitin ligase by hnRNP-U
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GENES & DEVELOPMENT (2002)
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EMBO JOURNAL (2002)
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling
G Polekhina et al.
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Multisite phosphorylation and the countdown to S phase
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CELL (2001)
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Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
NEDD8 recruits E2-ubiquitin to SCF E3 ligase
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EMBO JOURNAL (2001)
In vivo action of the HRD ubiquitin ligase complex:: Mechanisms of endoplasmic reticulum quality control and sterol regulation
RG Gardner et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
HIFα targeted for VHL-mediated destruction by proline hydroxylation:: Implications for O2 sensing
M Ivan et al.
SCIENCE (2001)
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
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SCIENCE (2001)
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CELL (2000)
Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex
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JOURNAL OF CELL BIOLOGY (2000)
Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway
GC Turner et al.
NATURE (2000)
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
Y Yang et al.
SCIENCE (2000)
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
SY Fang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The U box is a modified RING finger - a common domain in ubiquitination
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Recognition of the polyubiquitin proteolytic signal
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