期刊
ANNUAL REVIEW OF BIOCHEMISTRY
卷 78, 期 -, 页码 335-361出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.76.052705.164655
关键词
antibiotics; catalysis; elongation factors; fidelity; termination
资金
- NIH
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM058750] Funding Source: NIH RePORTER
RNA polymerase (RNA-P) is a complex molecular machine that governs gene expression and its regulation in all cellular organisms. To accomplish its function of accurately producing a full-length RNA copy of a gene, RNAP performs a plethora of chemical reactions and undergoes multiple conformational changes in response to cellular conditions. At the heart of this machine is the active center, the engine, which is composed of distinct fixed and moving parts that serve as the ultimate acceptor of regulatory signals and as the target of inhibitory drugs. Recent advances in the structural and biochemical characterization of RNAP explain the active center at the atomic level and enable ne,,v approaches to understanding the entire transcription mechanism, its exceptional fidelity and control.
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