期刊
ANNUAL REVIEW OF BIOCHEMISTRY
卷 78, 期 -, 页码 541-568出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.78.070907.103305
关键词
chemical biology; human proteins; structural genomics
资金
- Canadian Institutes for Health Research [1097737]
- Canadian Foundation for Innovation
- Genome Canada through the Ontario Genomics Institute
- GlaxoSimthKline
- Karolinska InstitutetKnut and Alice Wallenberg Foundation
- Ontario Innovation Trust
- Ontario Ministry for Research and Innovation
- Merck Co., Inc
- Novartis Research Foundation
- Swedish Agency for Innovation Systems
- Swedish Foundation for Strategic Research
- Wellcome Trust
- National Institutes of Health [GM074942]
- U.S. Department of Energy, Office of Biological and Environmental Research [DE-AC02-06CH11357.]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U54GM074942] Funding Source: NIH RePORTER
The large-scale structural biology projects that target human proteins focus predominantly on the catalytic domains of potential therapeutic targets and the domains of human proteins that mediate protein-protein and protein-small-molecule interactions. Their main scientific objective is to elucidate the molecular basis for specificity and selectivity of function within large protein families of therapeutic interest, such as kinases, phosphatases, and proteins involved in epigenetic regulation. Half of the unique human protein structures determined in the past three years derive from these initiatives.
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