期刊
ANNUAL REVIEW OF BIOCHEMISTRY
卷 78, 期 -, 页码 435-475出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.013008.092711
关键词
activation; downregulation; phosphorylation; ubiquitin
资金
- National Cancer Institute [5R01CA109035]
- Pediatric Brain Tumor Foundation
- Brain Tumor Society Research
- Phi Beta Psi Sorority Research Grant
- The University of Texas M. D. Anderson Cancer Center
- National Cancer Institute grant [CA80100, CA82683, CA116402]
- NATIONAL CANCER INSTITUTE [R01CA082683, R01CA116402, R01CA080100, R01CA109035] Funding Source: NIH RePORTER
Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly, initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity, or expression levels can cause human diseases.
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