期刊
ANNUAL REVIEW OF BIOCHEMISTRY
卷 77, 期 -, 页码 755-776出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.77.061606.161055
关键词
Fenton reaction; hydroxyl radical; iron; OxyR; PerR; SoxR
资金
- NIGMS NIH HHS [GM 49640, R37 GM049640, R37 GM049640-16, R01 GM049640] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R37GM049640, R01GM049640] Funding Source: NIH RePORTER
Life evolved in an anaerobic world; therefore, fundamental enzymatic mechanisms and biochemical pathways were refined and integrated into metabolism in the absence of any selective pressure to avoid reactivity with oxygen. After photosystem II appeared, environmental oxygen levels rose very slowly. During this time, microorganisms acquired oxygen tolerance by jettisoning enzymes that use glycyl radicals and exposed low-potential iron-sulfur clusters, which can be directly poisoned by oxygen. They also developed mechanisms to defend themselves against superoxide (O-2(-)) and hydrogen peroxide, partially reduced oxygen species that are generated as inadvertent by-products of aerobic metabolism. Contemporary organisms have inherited both the vulnerabilities and the defenses of these ancestral microbes. Current research seeks to identify these, and bacteria comprise an exceptionally accessible experimental system that has provided many of the answers. This manuscript reviews recent developments and identifies remaining puzzles.
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