期刊
ANNUAL REVIEW OF BIOCHEMISTRY
卷 77, 期 -, 页码 313-338出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.77.061306.123941
关键词
cancer; genome stability; neurodegeneration; recombination; repair; replication
资金
- NATIONAL CANCER INSTITUTE [P01CA092584] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES012512] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM047251, R29GM047251, R01GM057479, R01GM052504] Funding Source: NIH RePORTER
- NCI NIH HHS [P01 CA092584, P01 CA 92584] Funding Source: Medline
- NIEHS NIH HHS [R01 ES012512, ES 12512] Funding Source: Medline
- NIGMS NIH HHS [GM 57479, GM 47251, R01 GM057479, GM 52504, R01 GM052504-14, R01 GM047251, R01 GM052504] Funding Source: Medline
DNA ligases are required for DNA replication, repair, and recombination. In eukaryotes, there are three families of ATP-dependent DNA ligases. Members of the DNA ligase I and IV families are found in all eukaryotes, whereas DNA ligase III family members are restricted to vertebrates. These enzymes share a common catalytic region comprising a DNA-binding domain, a nucleotidyltransferase (NTase) domain, and an oligonucleotide/oligosaccharide binding (OB)-fold domain. The catalytic region encircles nicked DNA with each of the domains contacting the DNA duplex. The unique segments adjacent to the catalytic region of eukaryotic DNA ligases are involved in specific protein-protein interactions with a growing number of DNA replication and repair proteins. These interactions determine the specific cellular functions of the DNA ligase isozymes. In mammals, defects in DNA ligation have been linked with an increased incidence of cancer and neurodegeneration.
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