期刊
PUBLIC HEALTH NUTRITION
卷 8, 期 8, 页码 1322-1327出版社
CABI PUBLISHING
DOI: 10.1079/PHN2005750
关键词
fat intake; obesity; bias; epidemiology
Objective: To describe the consequences of systematic reporting bias by the obese for diet-disease relationships. Design: The present report used 24-hour urinary nitrogen and estimates of 24-hour energy expenditure to assess error in diet reporting, and examined the consequence of accounting for this error for associations between dietary fat intake and serum low-density lipoprotein (LDL)-cholesterol. Setting: Sub-study to the Danish MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) project, carried out in 1987-1988. Subjects: A random sub-sample of the adult Danish male population (n=152). Results: Correcting dietary fat for underreporting error weakened, rather than strengthened, the association between dietary fat intake and LDL-cholesterol by reducing the slope of the regression from beta=3.4, P=0.02 to beta=2.7, P=0.04. Conclusion: This example illustrates that systematic underreporting of dietary fat by high-risk groups such as the obese may produce an overestimated association. These results imply that previous epidemiological studies showing a positive association between percentage of energy from fat and other health outcomes, e.g. cancer and heart disease, may have overestimated the negative effects of a high-fat diet. If we were able to correctly assess dietary fat intake in general populations, recommendations for fat intake may be more liberal than the 30% suggested today. Improved assessment of fat intake in epidemiological studies is necessary for future development of evidence-based recommendations for diet and health .
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