期刊
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY
卷 1, 期 -, 页码 357-396出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.anchem.1.031207.112855
关键词
proteomics; metabonomics; biomarker; medicinal chemistry; bioanalytical; biotransformation
Current drug discovery involves a highly iterative process pertaining to three core disciplines: biology, chemistry and drug disposition. For most pharmaceutical companies the path to a drug Candidate comprises similar stages: target identification, biological screening, lead generation, lead optimization, and candidate selection. Over the past decade, the overall efficiency of drug discovery has been greatly improved by a single instrumental technique, liquid chromatography/mass spectrometry (LC/MS). Transformed by the commercial introduction of the atmospheric pressure ionization interface ill the mid-1990s, LC/MS has expanded into almost every area of drug discovery. In many cases, drug discovery workflow has been changed owing to vastly improved efficiency. This review examines recent trends for these three core disciplines and presents seminal examples where LC/MS has altered the current approach to drug, discovery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据