期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 33, 期 -, 页码 1375-1377出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0331375
关键词
disulphide; glutaredoxin (Grx); GSH; thiol redox control; thioredoxin (Trx); thioredoxin reductase (TrxR)
The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.
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