期刊
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY
卷 1, 期 -, 页码 329-355出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.anchem.1.031207.113038
关键词
amperometry; chronoamperometry; electroporation; microfluidics; microelectrodes
资金
- National Institutes of Health
- National Science Foundation
- European Union
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000352] Funding Source: NIH RePORTER
This article reviews recent work involving electrochemical methods for in vitro analysis of biomolecules., with an emphasis on detection and manipulation It and Of single cells and Cultures Of Cells. The techniques discussed include constant potential amperometry, chronoamperometry, cellular electroporation, scanning electrochemical microscopy, and microfluidic platforms integrated with electrochemical detection. The principles of these methods are briefly described, followed in most cases with a short description of an analytical or biological application and its significance. The use of electrochemical methods to examine specific mechanistic issues in exocytosis is highlighted, as a great deal of recent work has been devoted to this application.
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