期刊
IMMUNITY
卷 23, 期 6, 页码 599-609出版社
CELL PRESS
DOI: 10.1016/j.immuni.2005.10.009
关键词
-
类别
资金
- NCRR NIH HHS [P20 RR015577, P20-RR15577] Funding Source: Medline
- NIAID NIH HHS [R01 AI058162, AI58162, R01 AI020069, AI20069] Funding Source: Medline
beta-catenin-mediated Wnt signaling may contribute to the self-renewal of hematopoietic stem cells and proliferation in some malignancies. We now show that expression of constitutively active P-catenin in normal lymphoid or myeloid progenitors generated uncommitted cells with multilineage differentiation potential. Inappropriate gene expression occurred in cells destined to produce either cell type and caused corresponding changes in their characteristics. For example, forced activation of beta-catenin quickly increased C/EBP alpha while reducing EBF and Pax-5 in lymphoid progenitors that then generated myeloid cells. Inversely, EBF dramatically increased in transduced myeloid progenitors and lymphocytes were produced. The results indicate that ectopic activation of beta-catenin destabilizes lineage fate decisions and confers some, but not all, stem cell properties on committed progenitors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据