期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 115, 期 12, 页码 3594-3601出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI24609
关键词
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资金
- NIAID NIH HHS [R01 AI053075-01A1, R01 AI053075-04S1, R01 AI053075-02, 5-R01-AI053075-02, R01 AI053075, R01 AI053075-03, R01 AI053075-05, R01 AI053075-04] Funding Source: Medline
Whooping cough is considered a childhood disease, although there is growing evidence that children are infected by adult carriers. Additionally, increasing numbers of vaccinated adults are being diagnosed with Bordetella pertussis disease. Thus it is critical to understand how B. pertussis remains endemic even in highly vaccinated or immune populations. Here we used the mouse model to examine the nature of sterilizing immunity to B. pertussis. Antibodies were necessary to control infection but did not rapidly clear B. pertussis from the lungs. However, antibodies affected B. pertussis after a delay of at least a week by a mechanism that involved neutrophils and Fc receptors, suggesting that neutrophils phagocyrose and clear antiody-opsonized bacteria via Fc receptors. B. pertussis blocked migration of neutrophils and inhibited their recruitment to the lungs during the first week of infection by a pertussis toxin-dependent (PTx-dependent) mechanism; a PTx mutant of B. pertussis induced rapid neutrophil recruitment and was rapidly cleared from the lungs by adoptively transferred antibodies. Depletion of neutrophils abrogated the defects of the PTx mutant. Together these results indicate that PTx inhibits neutrophil recruitment, which consequently allows B. pertussis to avoid rapid antibody-mediated clearance and therefore successfully infect immune hosts.
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