期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 289, 期 6, 页码 G981-G986出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00363.2005
关键词
anemia; duodenal cytochrome B; divalent metal ion transporter; ferroportin; hemochromatosis; iron absorption; Nramp2; SLC11A2
资金
- NIDDK NIH HHS [DK-59764] Funding Source: Medline
How does iron enter enterocytes? Ablating SLC11A2, the gene for the divalent metal ion transporter DMT1, supports evidence from the Belgrade rat and mk mouse models establishing DMT1 as the primary mechanism serving apical uptake of nonheme iron. DMT1 harnesses the energy from the proton electrochemical potential gradient to drive active transport of Fe2+ ( and perhaps Mn2+ and other metal ions) into enterocytes. Fe(III) must first be reduced by ascorbic acid and surface ferrireductases. Among these is duodenal cytochrome B (DcytB), but lack of an obvious phenotype in DcytB (Cybrd1) knockout mice suggests ferrireductase redundancy. Our understanding of heme absorption lagged, but the time is ripe for gains.
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