期刊
NANO LETTERS
卷 5, 期 12, 页码 2552-2556出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl0519229
关键词
-
类别
资金
- NCI NIH HHS [T32 CA 79443, CA 101078 1, P50 CA 86355] Funding Source: Medline
- NHLBI NIH HHS [R01 HL 080731] Funding Source: Medline
We report the production of poly(lactic-co-glycolic acid) nanoparticles that encapsulate the photosensitizer meso-tetraphenylporpholactol. These nanoparticles are stable and nonphototoxic upon systemic administration. Upon cellular internalization, the photosensitizer is released from the nanoparticle and becomes highly phototoxic. Irradiation with visible light results in cell-specific killing of several cancer cell lines. Importantly, in vivo experiments show complete eradication of cancers in mouse models. The concept of photosensitizers with selective phototoxicity should have widespread applications in cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据