期刊
NATURE METHODS
卷 2, 期 12, 页码 955-957出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH811
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资金
- Biotechnology and Biological Sciences Research Council [S19816] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [S19816] Funding Source: Medline
Bottom-up proteomics is the analysis of peptides derived from single proteins or protein mixtures, and because each protein generates tens of peptides, there is scope for controlled reduction in complexity. We report here a new strategy for selective isolation of the N-terminal peptides of a protein mixture, yielding positionally defined peptides. The method is tolerant of several fragmentation methods, and the databases that must be searched are substantially less complex.
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