期刊
MATERIALS LETTERS
卷 59, 期 29-30, 页码 4000-4005出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2005.07.062
关键词
interpenetrating composite; calcium phosphate cement; tricalcium phosphate; poly(DL-lactide-co-glycolide)
The purpose of this study was to fabricate composites consisting of three interpenetrating networks: tricalcium phosphate (TCP), hydroxyapatite (HA), and poly(DL-lactide-co-glycolide) (PLGA). The porous TCP network was first produced by coating a polyurethane (PU) foam with hydrolysable alpha-TCP slurry. The HA network was derived from a calcium phosphate cement (CPC) filled in the porous TCP network. The remaining open pore network in the HA/TCP composite was further infiltrated with a PLGA network. The three sets of spatially continuous networks would have different biodegradation rates and thus bone tissue would grow towards the fastest biodegrading network while the remaining networks still maintaining their geometrical shape and carrying the physiological load for the tissue ingrowth. (C) 2005 Elsevier B.V. All rights reserved.
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