期刊
NATURE CELL BIOLOGY
卷 7, 期 12, 页码 1191-1201出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1327
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- NCI NIH HHS [CA098402] Funding Source: Medline
- NIGMS NIH HHS [GM62931] Funding Source: Medline
- NINDS NIH HHS [NS26084] Funding Source: Medline
Signalling activity of the Notch receptor, which plays a fundamental role in metazoan cell fate determination, is controlled at multiple levels. We uncovered a Notch signal-controlling mechanism that depends on the ability of the non-visual P-arrestin, Kurtz (Krz), to influence the degradation and, consequently, the function of the Notch receptor. We identified Krz as a binding partner of a known Notch-pathway modulator, Deltex (Dx), and demonstrated the existence of a trimeric Notch-Dx-Krz protein complex. This complex mediates the degradation of the Notch receptor through a ubiquitination-dependent pathway. Our results establish a novel mode of regulation of Notch signalling and define a new function for non-visual beta-arrestins.
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