期刊
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
卷 18, 期 4, 页码 218-223出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0891988705281869
关键词
Alzheimer's disease; biomarkers; prevention
资金
- NIA NIH HHS [R01 AG009862, R01 AG009862-14, R01AG09862] Funding Source: Medline
Numerous studies show that the pathology of Alzheimer's disease is present decades before a clinical diagnosis of dementia can be made. Given the likelihood that agents will become available that reliably delay onset and/or slow progression of Alzheimer's disease, it will be important to detect preclinical Alzheimer's disease as early as possible for maximal treatment effect. Detection of individuals by sensitive cognitive measures provides one way to identify people who are at high risk of developing clinical Alzheimer's disease. However, it is likely that those with considerable brain or cognitive reserve will be able to mask cognitive deficits until very close to the onset of the dementia, rendering such cognitive measures insensitive. Optimum biomarkers for Alzheimer's disease therefore need to target the severity of underlying brain pathology independently of brain reserve. Findings are presented showing the importance of higher education and larger brain size in masking the underlying disease pathology.
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