期刊
BEHAVIORAL NEUROSCIENCE
卷 119, 期 6, 页码 1662-1671出版社
AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION
DOI: 10.1037/0735-7044.119.6.1662
关键词
conditioned fear; extinction; freezing; propranolol; epinephrine
资金
- Wellcome Trust [063095/Z/00/Z] Funding Source: Medline
Five experiments examined the reinstatement of fear (freezing) produced by recent reexposure to a dangerous context. Rats were trained to fear a conditioned stimulus (CS) and a distinctive context with shock. The CS was then extinguished. A 2-min interval between reexposure to the dangerous context and presentation of the extinguished CS in a different context reinstated freezing when the CS was tested the next day. Propranolol (a beta-adrenergic antagonist) blocked reinstatement of extinguished fear without decreasing freezing to a nonextinguished CS. Administration of epinephrine (an adrenergic agonist) reinstated extinguished fear without reexposure to the dangerous context. The results suggest a role for beta-adrenergic activity elicited by exposure to a conditioned context in the reinstatement of extinguished fear.
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