期刊
MOLECULAR THERAPY
卷 12, 期 6, 页码 1130-1141出版社
CELL PRESS
DOI: 10.1016/j.ymthe.2005.07.686
关键词
stem cells; myoblasts; cell transplantation; myocardial infarction; cardiac function tests; cell fusion; immunohistochemistry; angiogenesis; VEGF; oxidative stress
资金
- NCRR NIH HHS [C06 RR 14489] Funding Source: Medline
- NHLBI NIH HHS [R01 HL 069368, R01 HL 65219-04] Funding Source: Medline
- NIAMS NIH HHS [1U54 AR 050733-01] Funding Source: Medline
Myoblast transplantation for cardiac repair has generated beneficial results in both animals and humans; however, poor viability and poor engraftment of myoblasts after implantation in vivo limit their regeneration capacity. We and others have identified and isolated a subpopulation of skeletal muscle-derived stem cells (MDSCs) that regenerate skeletal muscle more effectively than myoblasts. Here we report that in comparison with a myoblast population, MDSCs implanted into infarcted hearts displayed greater and more persistent engraftment, induced more neoangiogenesis through graft expression of vascular endothelial growth factor, prevented cardiac remodeling, and elicited significant improvements in cardiac function. MDSCs also exhibited a greater ability to resist oxidative stress-induced apoptosis compared to myoblasts, which may partially explain the improved engraftment of MDSCs. These findings indicate that MDSCs constitute an alternative to other myogenic cells for use in cardiac repair applications.
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