期刊
CELL CYCLE
卷 4, 期 12, 页码 1758-1760出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.4.12.2153
关键词
aneuploidy; neurons; Alzheimer's disease; stem cells; progenitor cells; fluorescence in situ hybridization
类别
资金
- Intramural NIH HHS Funding Source: Medline
Neurons, once committed, exit the cell cycle and undergo maturation that promote specialized activity and are believed to operate upon a stable genome. We used fluorescence in situ hybridization, selective cell microdissection, and loss of heterozygosity analysis to assess degree of aneuploidy in patients with a neurodegenerative disease and in normal controls. We found that aneuploidy occurs in approximately 40% of mature, adult human neurons in health or disease and may be a physiological mechanism that maintains neuronal fate and function; it does not appear to be an unstable state. The fact that neuronal stem cells can be identified in adult humans and that somatic mosaicism may be found in neuronal precursor cells deserves further investigation before using adult neural stem cells to treat human disease.
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