期刊
CELL CYCLE
卷 4, 期 12, 页码 1749-1752出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.4.12.2224
关键词
LOXL2; Snail; E-cadherin; EMT; GSK-3 beta
类别
Epithelial-mesenchymal transition (EMT) is considered as an essential determinant of carcinoma progression. The transcription factor Snail controls EMT by repressing E-cadherin gene expression and other epithelial genes. Snail protein stability and cellular localization is finely controlled by GSK3 beta-dependent phosphorylation and subsequent ubiquitination. GSK3 beta phosphorylates Snail at two different motifs which induce its nuclear export and association with beta-Trcp thus leading to Snail degradation. Recently, Snail was found to interact physical and functionally with LOXL2, a member of the lysyl oxidase gene family. Interestingly, LOXL2 seems to attenuate the GSK3 beta-dependent Snail degradation. Here, we discuss the relevance of this new potential mechanism of regulation and the role of LOXL2 during carcinoma progression.
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